Blood Folates Deficiencies and Cognitive Functions in Aging.
Rapin JR, Le Poncin M, Grebyl J.
In Steinhagen-Thiessen E and Knook DL, ed. Trends in Biomedical Gerontology. Vol. 1. Rijswijk, The Netherlands: TNO Institute for Experimental Gerontology; 1987:221-223.


Abstract

Folate deficiencies studied in 38 old persons (62 + 5 years) are accompanied by neuropsychiatric disturbances such as depression, asthenia, irritability, forgetfulness and lack of attention. These symptoms disappear with a treatment by folinic acid.

High dose folate significantly improved:9
- visual-spatial memory 3
- perception and visual-spatial
- organization 5
- associative memory 10
- logical reasoning 12
- maze delay 13

Lists of test in order without significant change:
1-Rey auditory and verbal learning 2-stages of memorization visuo verbal, learning capacity, immediate and delayed recall, 4-verbal interferences, 8-psychomotor coordination, 9-object test, 11-verbal learning, 15-overlapped drawing and 16-perception and ability to discriminate figures. Not shown 6-reaction time test (visual), 7-reaction time test (auditory), 14-recall of visuo spatial memory.